Cerebellar & Ataxia Disorders

Hereditary and acquired ataxias have a rapidly growing therapeutic pipeline with multiple disease-specific approvals. The session covers spinocerebellar ataxia (SCA) genetics, Friedreich ataxia (FA) and omaveloxolone (Skyclarys), gluten ataxia and gluten-free diet response, paraneoplastic cerebellar degeneration, multiple system atrophy cerebellar type, and emerging gene therapies for SCA. Discussion addresses cerebellar imaging including MR spectroscopy and DAT-SPECT, episodic ataxia genetics and management, cerebellar cognitive affective syndrome, ataxia-telangiectasia and DNA-repair disorders, and the international ataxia registries (CRC-SCA, GEM-NPA) driving natural-history research.